Postdoctoral Researcher – Cell & Chemical Biology

UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

www.uhn.ca

Position Summary:
We are seeking a highly motivated postdoctoral researcher with a strong background in quantitative cell and cancer biology to characterize small-molecule chemical probes targeting novel cancer-related proteins. We focus on regulators of posttranslational modifications, such as protein methylation and ubiquitylation, which play key roles in cancer cell survival. The successful candidate will apply cutting-edge cellular screening methods, pathway analysis, cell model development, and direct-to-biology assays for compound evaluation, integrated with machine learning models to guide compound discovery. Through evaluation of pharmacological pathway modulation in cancer, the Fellow will accelerate the discovery of novel therapeutic targets and chemical probes to understand human health and disease and seed drug discovery.

In this unparalleled training opportunity, the Fellow will be supported by a dynamic project team working in close collaboration with experienced biochemists, structural biologists, medicinal chemists, machine learning scientists, and cell biologists from the Structural Genomics Consortium (SGC) and Industry and technology partners.

The Target 2035 Fellow will be supervised by Dr. Barsyte-Lovejoy, Principal Investigator at SGC, Associate Professor in the Pharmacology and Toxicology Department at the University of Toronto, and an affiliate scientist at the Princess Margaret Cancer Centre, and will be co-supervised with an industry partner of SGC. This position is part of the Target 2035 Fellows program, supported through a Mitacs Accelerate Umbrella program coordinated by SGC. The fellowship is offered as a temporary full-time postdoctoral appointment for an initial one-year term, with the possibility of renewal for up to two additional years, subject to performance, funding availability, and program requirements.

The Fellow will be embedded within SGC’s research environment at the University Health Network and will contribute to collaborative research aligned with Target 2035, a global open science initiative focused on accelerating early drug discovery through the generation of high-quality chemical tools and protein-ligand interaction data. Training is provided through academic supervision, day-to-day integration within SGC research teams, and participation in collaborative projects involving academic, technology, and industry partners. All research outputs generated under the program adhere to SGC’s open science principles.

Duties:

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.