Postdoctoral Researcher

UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

www.uhn.ca

More than 250 million people are chronically infected with Hepatitis B virus (HBV) with no effective cure. My lab is part of the Toronto Centre for Liver Disease, one of the largest liver clinics in North America, with an active clinical trial research program testing novel hepatitis B therapies in Phase 1- 3 clinical trials. New studies are incorporating longitudinal liver sampling with single-cell RNA sequencing (scRNAseq) to better understand the intrahepatic immune response to novel treatments in the context of viral control and liver inflammation.

We are looking for a bioinformatician with demonstrated experience single-cell RNA sequencing analysis and an interest in incorporating new artificial intelligence tools into the analysis pipeline. The anticipation is that this qualified person will be able to work with large scRNAseq datasets with cell numbers >3,000,000 cells and be able to code in relevant languages to incorporate the latest analysis tools.

This is an opportunity to work with state-of-the-art data in the context of novel drugs in early-stage clinical trials. The position will involve industry collaboration with the expectation of academic publication. There will also be internal opportunities for collaboration in our basic research projects focused HBV pathogenesis using similar samples.

Duties

The successful applicant will be expected