Postdoctoral Researcher

UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

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Position Summary
Within this position, the Postdoctoral Researcher will pursue research on gene editing of APP and other genes causing familial Alzheimer’s disease. The studies will include the design of components required for prime editing, as well as the development of efficient delivery methods. Apart from correcting disease-causing mutations, the potential of introducing protective mutations will be explored. These strategies will be evaluated on cellular and mouse disease models, in order to determine whether APP editing can reduce pathogenic effects caused by amyloid-beta. In addition to gene editing, the applicant will have the opportunity to be involved in ongoing projects, e.g. development of novel strategies for anti amyloid-beta immunotherapy.

The application should contain a cover letter (maximum 1 page) describing the applicant’s research interests, an updated CV with a list of publications, and copies of diplomas and certificates of higher academic degrees. Please submit as one file.

Duties:

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Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.