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Job Posting #865117
Position: Post-Doctoral Fellow
Site: Princess Margaret Research Institute
Reports to: Principal Investigator
Hours: 37.5 per week
Status: Temporary Full-Time
University Health Network (UHN) is looking for an experienced professional to fill the key role of Post-Doctoral Fellow in the Kridel Lab.
Transforming lives and communities through excellence in care, discovery and learning.
The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto Rehabilitation Institute, Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre and the Michener Institute of Education at UHN. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of groundbreaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.
University Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network. The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. Research across UHN's five research institutes spans the full spectrum of diseases and disciplines, including cancer, cardiovascular sciences, transplantation, neural and sensory sciences, musculoskeletal health, rehabilitation sciences, and community and population health. Find out about our purpose, values and principles here.
Postdoctoral Fellowship in Computational Cancer Biology:
Translational Research in Lymphoid Malignancies
@ Princess Margaret Cancer Centre (Toronto, Canada)
The Kridel lab is seeking a talented postdoctoral fellow to lead our circulating tumour DNA project in lymphoid malignancies. We are leveraging samples from a large cohort of prospectively acquired plasma samples (“liquid biopsies”) to define DNA mutation- and epigenomic-based biomarkers. The overall aim is to robustly detect lymphoma in plasma samples, accurately classify lymphoma subtypes and monitor tumour evolution over time. This project is linked to other similar efforts at our institution, and collaboration with other internal and external groups is expected. The successful candidate will be embedded in a rich scientific environment that provides ample opportunities for development of technical, as well as leadership skills. Highly motivated individuals with a desire to make an impact in the field of cancer genomics are encouraged to apply.
The circulating tumour DNA project is new direction for our lab. For other, representative projects please consider the following references:
• Molecular Attributes Underlying Central Nervous System and Systemic Relapse in Diffuse Large B-cell Lymphoma. Isaev K, … Scott DW, Kridel R. Haematologica. 2020 Aug 13; Online ahead of print. PMID: 32817292
• Histological Transformation and Progression in Follicular Lymphoma: a Clonal Evolution Study. Kridel R, Chan FC, Mottok A, … Gascoyne RD, Shah P. PLOS Medicine. 2016 Dec 13;13(12):e1002197. PMID: 27959929.
• Integration of Gene Mutations Improves Risk Prognostication in Patients Receiving First-line Immunochemotherapy for Follicular Lymphoma in Clinical Trial and Population-Based Cohorts. Pastore A, Jurinovic V, Kridel R, Hoster E, … Gascoyne RD, Weinstock DM, Weigert O. Lancet Oncol. 2015 Sep;16(9):1111-22. PMID: 26256760.
• Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma. Kridel R, Meissner B, … Weng AP, Steidl C, Gascoyne RD. Plenary Paper. Blood. 2012 Mar 1;119(9):1963-71. PMID: 22210878.
The PDF should hold a PhD degree in bioinformatics, computer science, statistics or molecular biology, possess exceptional computational skills and experience with cancer genomics. Excellent communication skills are required, as is the willingness to work in a team environment.
We have an interest in B-cell lymphomas and are focusing on scenarios that are associated with poor outcome such as early progression after treatment, transformation to aggressive lymphoma and relapse in the central nervous system. We are applying cutting-edge tools to primary patient samples to unravel tumour heterogeneity and to develop novel, innovative biomarkers to predict outcome in lymphoma. Furthermore, we are leveraging novel findings from discovery platforms to elucidate mechanisms of lymphoma pathogenesis and treatment resistance. Our ultimate goal is to improve patient outcomes through a better understanding of the diversity of responses to treatment and by tailoring therapy to each individual patient. See our lab website for further information: https://kridel-lab.ca/.
Princess Margaret Cancer Centre:
The Princess Margaret Cancer Centre (PMCC) is one of the top 5 cancer centres in the world. PMCC is a teaching hospital within the University Health Network and affiliated with the University of Toronto, with the largest cancer research program in Canada. This rich working environment provides ample opportunities for collaboration and scientific exchange with a large community of clinical, genomics, computational biology and machine learning groups at the University of Toronto and associated institutions, such as the Ontario Institute of Cancer Research, Hospital for Sick Children and Donnelly Centre.
If you are interested in making your contribution at UHN, please apply on-line. You will be asked to copy and paste as well as attach your resume and covering letter. You will also be required to complete some initial screening questions.
Posted Date: October 8, 2020 Closing Date: Until filled
For current UHN employees, only those who have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, and possess all the required experience and qualifications should apply.
University Health Network thanks all applicants, however, only those selected for an interview will be contacted.
UHN is a respectful, caring, and inclusive workplace. We are committed to championing accessibility, diversity and equal opportunity. Requests for accommodation can be made at any stage of the recruitment process providing the applicant has met the Bona-fide requirements for the open position. Applicants need to make their requirements known when contacted.
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